Infertility causes There are several causes or factors that cause infertility. For a better study and understanding, they are grouped as follows: Ovarian factor Tubarian factor Male factor Endometrial factor Embryonary factor Ovaric factor: anovulation We call ovaric factor the fact of women not ovulating. The most frequent causes for this factor are: Polycystic Ovary Syndrome (PCOS): : this is probably the most frequent endocrinologic alteration among infertile women. These patients suffer from a hormonal disadjustment and overproduction of certain masculine hormones, such as androgens, producing lack of menstruation and ovulation.